Hebei Yanxi Chemical Co., Ltd.  

Product Name: 103-81-1 2-Phenylacetamide/Phenylacetamide Used as an Intermediate in Drugs Purity: >98% State: White Crystal Certification: GMP Customized: Non-Customized Powder: Yes Trademark: YANXI Transport Package: 25kg /Bag Specification: 25 kg /bag Origin: China Hebei HS Code: 2824100000 Product Description Product descriptionCAS No.:103-81-1Synonyms:View More· Phenylacetamide;· Benzeneacetamide;· 2-PhenylacetaMide;· Ph-CH2-CO-NH2;· 2-phenyl-acetamide;· 2-Phenylacetamide;Formula:C8H9NOExact Mass:135.06800Molecular Weight:135.16300PSA:43.09000LogP:1.41470PropertiesFeedbackAppearance & Physical State:White krystalline powder.Density:1.098 g/cm3Melting Point:157-158ºCBoiling Point:280-290ºC (dec.)Flash Point:142.6ºCRefractive Index:1.552Vapor Pressure:0.000537mmHg at 25°CSafety InfoFeedbackRTECS:AC7705000Safety Statements:S22-S24/25HS Code:3004909099Hazard Codes:XiProduction methodsStyrene, sulfur, liquid ammonia and water into the autoclave, under 165 ºC, about 6.5 MPa pressure reaction, and then heated to steam and hurried to hydrogen sulfide gas, add active carbon decoloring, cooling, crystallization, filtration, drying and phenyl ethyl amide.This method can be improved for pipelining continuous production, styrene and ammonium polysulfide solution according to the volume ratio 1:2 to cooperate, through high pressure pipeline, reaction temperature is 200 ºC, reaction pressure for 6-7.8 MPa, the reaction time of 1.5 h.The post-treatment process of the reaction products was similar to that of the autoclave batch process.Raw material consumption quota: styrene (99%)1117kg/t, sulfur (98.5%)716kg/t, liquid ammonia (99%)539kg/t, activated carbon 47kg/t.Another method of production is to hydrolyze acetonitrile (produced by the reaction of benzyl chloride and sodium cyanide in an aqueous solution of dimethylamine) by heating in sulfuric or hydrochloric acid.Adding phenylacetonitrile concentrated hydrochloric acid, stir to dissolve and 50 ºCin half an hour.Then in the cooling slowly add water precipitation crystallization, cooling after filtration, wash with ice water to get the coarse product.The crude product was washed with sodium carbonate solution and then washed with ice water.Consumption quota of raw materials: benzyl chloride (95%)1190kg/t, sodium cyanide (95%)527kg/t, dimethylamine (industrial product)20kg/t, sodium carbonate (industrial product)185kg/t, sulfuric acid (92.5%)1760kg/t.useUsed as an intermediate in drugs such as penicillin and phenobarbital.It is also used to prepare phenylacetic acid, perfume and pesticide rodenticide.